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AMGEN
Pharmaceutical Companies
Amgen is one of the world’s leading biotechnology companies. Amgen is a values-based company, deeply rooted in science and innovation to transform new ideas and discoveries into medicines for patients with serious illnesses. Amgen is committed to unlocking the potential of biology for patients suffering from serious illnesses by discovering, developing, manufacturing and delivering innovative human therapeutics. This approach begins by using tools like advanced human genetics to unravel the complexities of disease and understand the fundamentals of human biology. Our belief—and the core of our strategy—is that innovative, highly differentiated medicines that provide large clinical benefits in addressing serious diseases are medicines that will not only help patients, but also will help reduce the social and economic burden of disease in society today. Amgen focuses on areas of high unmet medical need and leverages its expertise to strive for solutions that improve health outcomes and dramatically improve people's lives. A biotechnology innovator since 1980, Amgen has grown to be one of the world's leading independent biotechnology companies, has reached millions of patients around the world and is developing a pipeline of medicines with breakaway potential. We have a presence in approximately 100 countries and regions worldwide and our innovative medicines have reached millions of people in the fight against serious illnesses such as cancer, cardiovascular disease, osteoporosis, asthma, rheumatoid arthritis and many others. Our medicines typically address diseases for which there are limited treatment options, or they are medicines that provide a viable option to what is otherwise available. Understanding the fundamental biological mechanisms of disease is a defining feature of Amgen's discovery research efforts—and a major contributor to the development of Amgen's deep and broad pipeline of potential new medicines. Amgen's "biology first" approach permits its scientists to first explore the complex molecular pathways of disease before determining what type of medicine, or modality, is most likely to deliver optimal efficacy and safety. With the advances in human genetics, Amgen continues to shed new light on the molecular roots of disease. Amgen subsidiary deCODE Genetics, a global leader in human genetics, is a powerful differentiator, greatly improving how we identify and validate human disease targets. The treatment of millions of seriously ill patients worldwide depends on the safe and reliable production of biologic medicines, which are administered by injection or intravenously. A worldwide leader in biologics manufacturing, Amgen has an outstanding track record of reliably delivering high-quality medicines to patients who need them. Significant skill, experience, vigilance and commitment are critical to help ensure the quality of a biologic medicine each time a new batch is made. At Amgen, robust quality control and a reliable supply of medicines for patients are every bit as important as scientific innovation. While bringing innovative medicines to people suffering from serious diseases is the best way Amgen can contribute to the greater good, we know that society confronts multiple challenges and we are working to do our part to address them. Our efforts fall into four categories: Healthy People – We focus on removing barriers that limit equitable access to healthcare so that people can live their healthiest lives. In 2021, for example, the Amgen Safety Net Foundation provided $2.2 billion* worth of Amgen medicines at no cost to low-income Americans. Healthy Society – We work toward a more just society for our employees and the people we serve. For instance, Amgen is a founding member of the OneTen coalition, comprised of leading companies with a collective goal over the next 10 years to hire one million Black Americans into good-paying, family-sustaining jobs. Healthy Planet – We prioritize sustainability and aim to minimize our environmental impact to preserve natural resources for generations to come. In 2021, for example, Amgen announced plans to invest more than $200 million to become carbon neutral by 2027, while also reducing our water use by 40% and our waste generated by 70%. A Healthy Amgen – We hold ourselves to high standards in all we do to ensure our culture and products reflect Amgen values. Every year, for example, all Amgen employees around the world complete a comprehensive Code of Conduct training to reinforce how we must interact with each other, as well as with physicians, regulators, government officials, and other external stakeholders. Amgen’s medicines treat serious illnesses and typically address diseases with a limited number of treatment options. With a presence in approximately 100 countries, we are proud to have reached millions of people with our products. The product information provided below is intended for residents of the U.S. only. For information in other countries, please select your country from the Amgen Worldwide page . actimmune.com Prescribing Information For more information for healthcare professionals, visit actimmunehcp.com aimovig.com Prescribing Information Pricing Information For more information for healthcare professionals, visit aimovighcp.com amjevita.com Prescribing Information Medication Guide For more information for healthcare professionals, visit amjevitapro.com aranesp.com Prescribing Information Medication Guide Patient Instructions for Use - Vial Patient Instructions for Use - Prefilled Syringe avsola.com Prescribing Information Medication Guide blincyto.com Prescribing Information Medication Guide For more information for healthcare professionals, visit blincytohcp.com Prescribing Information corlanor.com Prescribing Information Medication Guide For more information for healthcare professionals, visit corlanorhcp.com enbrel.com Prescribing Information Medication Guide Patient Instructions for Use Pricing Information For more information for healthcare professionals, visit enbrel.com/HCP epogen.com Prescribing Information Medication Guide Patient Instructions for Use For more information for healthcare professionals, visit epogen.com/professional evenity.com Prescribing Information Medication Guide For more information for healthcare professionals, visit evenityproliahcp.com imlygic.com Prescribing Information Medication Guide For more information for healthcare professionals, visit imlygichcp.com kanjinti.com Prescribing Information krystexxa.com Prescribing Information Medication Guide For more information for healthcare professionals, visit krystexxahcp.com kyprolis.com Prescribing Information For more information for healthcare professionals, visit kyprolis-hcp.com lumakras.com Prescribing Information For more information for healthcare professionals, visit lumakrashcp.com mvasi.com Prescribing Information neulasta.com Prescribing Information Instructions for Use Pricing Information For more information for healthcare professionals, visit neulastahcp.com neupogen.com Prescribing Information For more information for healthcare professionals, visit neupogenhcp.com nplate.com Prescribing Information and Medication Guide For more information for healthcare professionals, visit nplatehcp.com otezla.com Prescribing Information For more information for healthcare professionals, visit otezlapro.com parsabiv.com Prescribing Information For more information for healthcare professionals, visit parsabivhcp.com procysbi.com Prescribing Information Patient Package Insert For more information for healthcare professionals, visit procysbihcp.com prolia.com Prescribing Information Medication Guide Pricing Information For more information for healthcare professionals, visit proliahcp.com ravicti.com Prescribing Information Medication Guide For more information for healthcare professionals, visit ravictihcp.com repatha.com Prescribing Information Pricing Information For more information for healthcare professionals, visit repathahcp.com riabni.com Prescribing Information Medication Guide sensipar.com Prescribing Information For more information for healthcare professionals, visit sensiparhcp.com tavneos.com Prescribing Information Medication Guide For more information for healthcare professionals, visit tavneos.com/hcp tepezza.com Prescribing Information For more information for healthcare professionals, visit www.tepezzahcp.com tezspire.com Prescribing Information For more information for healthcare professionals, visit tezspirehcp.com uplizna.com Prescribing Information Medication Guide For more information for healthcare professionals, visit upliznahcp.com vectibix.com Prescribing Information For more information for healthcare professionals, visit vectibixhcp.com xgeva.com Prescribing Information For more information for healthcare professionals, visit xgeva.com/hcp To learn more, please visit www.amgen.com/responsibility . Source: https://www.amgen.com/
Bayer AG
Pharmaceutical Companies
Millions of Americans are living with unmet health needs. At Bayer, our focus is to discover and develop medicines that provide the opportunity to live a healthier life. That’s why we’re continually expanding our pipeline portfolio in oncology and cardiovascular care, developing new approaches using cell and gene therapy, and delivering more options to help women make informed decisions about their health. Our portfolio also includes a long history of development in hematology and radiology. We are bringing forth new treatments and making investments in many disease areas. Yet, our work doesn’t stop in the lab because innovation alone isn’t enough. Bayer is committed to addressing issues that create barriers to access optimal care. We know that every positive health outcome begins with a commitment to focus on the individual. Each day, we are joining scientific and human approaches to create a complete focus on improving health for all Americans. Bayer is a Life Science company with a more than 150-year history and core competencies in the areas of health care and agriculture. With our innovative products, we are contributing to finding solutions to some of the major challenges of our time. Contributing to sustainable development is a core element of Bayer’s corporate strategy and of our core values. Guided by our vision “Health for all, Hunger for none”, we promote inclusive growth and a responsible use of resources to help people and planet thrive. Inclusive growth means we’re providing more people in all the regions of the world with access to health care and food security and devising solutions to environmental protection, esp. decarbonization, climate adaptation, and biodiversity preservation. Our products, services and innovative prowess enables us to contribute significantly toward meeting the United Nations’ Sustainable Development Goals with regard to combating hunger (Goal 2) and providing health care (Goal 3). Our work also helps the fight against poverty (Goal 1). In addition, we are sharpening our focus on empowering women (Goal 5),working on the availability and sustainable management of water for all (SDG 6), redoubling our efforts to reduce greenhouse gases along our value chain and build resilience towards the impacts of climate change (Goal 13) and protecting life on land (Goal 15). Source: https://www.bayer.com/en/ USA Source: https://www.bayer.com/en/us/bayer-united-states-of-america
Bristol-Myers Squibb
Pharmaceutical Companies
Bristol Myers Squibb is a global biopharmaceutical company focused on discovering, developing and delivering innovative medicines for patients. A Q&A with David Gordon, vice president, Cardiovascular and Fibrosis Discovery Biology NOVEMBER 10, 2021 Learn how Bristol Myers Squibb is advancing research in cardiovascular diseases from David Gordon , vice president, Cardiovascular and Fibrosis Discovery Biology. David: With advancing science, we are really starting to understand the underlying drivers of cardiovascular disease. Once we understand the root causes, we can then design therapies to directly address them, one by one. Matching the therapy to the patient based on the cause of their particular version of the disease is commonly referred to as “precision medicine.” It’s a concept that is currently being applied to Oncology but is just now finding its way into Cardiology. With a precision medicine approach in cardiovascular disease, we are trying to get away from the days when you needed 20,000 patients in a clinical trial in order to prove that a drug works. That many patients were required because we weren’t precisely matching the therapy to the cause and therefore, it didn’t work in a large percentage of the participants. We therefore needed that many patients to find the population where it did work. At Bristol Myers Squibb, we are dedicated to understanding underlying disease causes so that we can better address them. For instance, some individuals with cardiovascular disease have an underlying genetic cause. By identifying these causes, we can address them directly, for instance with advanced medicine, like gene therapy, or through a targeted approach. David: There is a major unmet need in heart failure. Specifically, heart failure with preserved ejection fraction (HFpEF). HFpEF can be very different from patient to patient which means that therapeutic selection should also be different. Once we can understand how to group patients into subpopulations, then we can figure out how to match up therapies to the patients rather than taking a “one-size-fits-all” approach that has failed many times in this population. We are applying many different technologies to try to accomplish this, such as using imaging and monitoring biomarkers. Eventually, our goal is to identify and validate predictive biomarkers that can match the patient to a therapy and determine how well they are going to respond. David: For more than 60 years, Bristol Myers Squibb has been a trailblazer in the fight against cardiovascular disease, bringing new and transformative therapies forward for patients. As a leader in cardiovascular research, we have pioneered the science behind many game-changing targets and over the years have translated this science into life-saving medicines that have treated millions of people around the world. We are committed to continuing that innovation as the field moves in more purposeful directions to solve some of the hardest problems challenging researchers working in heart failure. David: Bristol Myers Squibb collaborates with a broad range of partners, including biotechnology companies, other pharmaceutical companies, academic centers and patient advocates to progress science. We bring together companies and individuals with different knowledge bases and capabilities so that we can advance science faster as we all work toward the common goal of improving care for patients. David: I had an uncle whom I was very close to who suffered from heart failure. Watching him progress through the disease—his poor quality of life and the horrible impact of the disease on his caregivers, particularly my aunt—motivates me and has fueled my passion to help this community. Source: http://www.bms.com/
Cleveland Clinic - The Big 6 Heart Medications
Pharmaceutical Companies
Cleveland Clinic - The Big 6 Heart Medications Physicians today have an arsenal of medications they can prescribe to help their patients in the battle against heart disease. If you are a heart patient, you can expect to be taking one or more of these highly effective medications. As a heart patient, it’s important for you to understand what each medication does and how to use them safely, often in combination. When used appropriately and according to the proper prescription, these medications extend both quantity and quality of life by preventing heart attacks and strokes. Modern heart drug therapy includes the following “big six” medications: Statins were first introduced in 1987 and doctors now have seven different medications from which to choose depending on a patient’s need. They lower the “bad” LDL cholesterol levels by 20 to 60% and also reduce inflammation. Most people who have had a heart attack or stroke, bypass surgery, stents, or diabetes should be taking statins. Some patients with a high LDL level, but without heart disease, should also take statins. Aspirin has been around for a long time and was first discovered to have cardiovascular benefits in the 1960s. Aspirin can help to keep your arteries open because of its anti-clotting and anti-platelet effects. A standard dosage for heart patients is 81 mg a day, which is one baby aspirin. Aspirin makes sense for people who already have heart disease, but not necessarily for people who just have risk factors. But cardiologist Leslie Cho, MD , advises “we should emphasize that it’s really not recommended for primary prevention unless the ischemic benefit outweighs the bleeding risk.” This drug is considered a “super-aspirin” because of its effectiveness in preventing platelet clumping, and it’s often used in combination with aspirin. For some patients there is an increased risk of bleeding and doctors will weigh the benefits versus the risks of this drug. However, if you have a stent, the combination of aspirin and clopidogrel is essential to preventing clotting. It’s also often used for patients with worsening angina. Dr. Cho says if you’ve had acute coronary syndrome, a better option might be Ticagrelor or Prasugrel, however. 4. Warfarin — to prevent blood clots <img alt=Warfarin | Podcast | Chemistry World 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
Eli Lilly and Company
Pharmaceutical Companies
Lilly was founded in 1876 by Colonel Eli Lilly, a man committed to creating high-quality medicines that met real needs in an era of unreliable elixirs peddled by questionable characters. His charge to the generations of employees who have followed was this: "Take what you find here and make it better and better." More than 145 years later, we remain committed to his vision through every aspect of our business and the people we serve starting with those who take our medicines, and extending to health care professionals, employees and the communities in which we live. It's the spirit that has defined us since the day Colonel Eli Lilly opened the doors of our first laboratory in Indianapolis. Over 140 years and nearly 100 medicines later, we keep looking for the next great discovery and for even more ways to make life better for people around the world. Source: https://www.lilly.com/
GlaxoSmithKline
Pharmaceutical Companies
We have three global businesses that research, develop and manufacture innovative pharmaceutical medicines, vaccines and consumer healthcare products. We are a science-led global healthcare company with a special purpose to improve the quality of human life by helping people do more, feel better, live longer. Every day, we help improve the health of millions of people around the world by discovering, developing and manufacturing innovative medicines, vaccines and consumer healthcare products. We are building a stronger purpose and performance culture underpinned by our values and expectations - so that together we can deliver extraordinary impact for patients and consumers and make GSK a brilliant place to work. Our values are Patient focus, Transparency, Respect, Integrity. Our expectations are Courage, Accountability, Development, Teamwork. Source: https://www.gsk.com/
Heart Health Drugs Explained
Pharmaceutical Companies
If you've had a heart attack , you will most likely be prescribed medication that you will take for the rest of your life. There are many types and combinations of drugs used to treat coronary artery disease (CAD) , and your doctor or other health care provider will decide the best treatment combination for your situation. The following gives you a quick look at many typical cardiac medications. Your prescription may have a different name from the ones listed on this chart. Brand names commonly available in the U.S. are shown in parentheses after the generic name for each drug. *Some of the major types of commonly prescribed cardiovascular medications are summarized in this section. For your information and reference, we have included generic names as well as major trade names to help you identify what you may be taking. However, the AHA is not recommending or endorsing any specific products . If your prescription medication isn't on this list, remember that your healthcare provider and pharmacist are your best sources of information. It's important to discuss all of the drugs you take with your provider and understand their desired effects and possible side effects. Never stop taking a medication and never change your dose or frequency without first consulting the prescribing doctor. Anticoagulants Antiplatelet Agents and Dual Antiplatelet Therapy ACE Inhibitors Angiotensin II Receptor Blockers Angiotensin Receptor-Neprilysin Inhibitors Beta Blockers Calcium Channel Blockers Cholesterol-lowering medications Digitalis Preparations Diuretics Vasodilators (Also known as Blood Thinners. Commonly prescribed include: Apixaban (Eliquis) Dabigatran (Pradaxa) Edoxaban (Savaysa) Heparin (various) Rivaroxaban (Xarelto) Warfarin (Coumadin) What the Medication Does Decreases the clotting (coagulating) ability of the blood. Sometimes called blood thinners, although they do not actually thin the blood. They do NOT dissolve existing blood clots. Used to treat certain blood vessel, heart and lung conditions. Reason for Medication Helps to prevent harmful clots from forming in the blood vessels. May prevent the clots from becoming larger and causing more serious problems. Often prescribed to prevent first or recurrent stroke. Commonly prescribed include: Aspirin Clopidogrel (Plavix) Dipyridamole (Persantine) Prasugrel (Effient) Ticagrelor (Brilinta) What the Medication Does Keeps blood clots from forming by preventing blood platelets from sticking together. Reason for Medication Helps prevent clotting in patients who have had a heart attack , unstable angina, ischemic strokes, TIA (transient ischemic attacks) and other forms of cardiovascular disease. Can also be prescribed preventively when plaque buildup is evident but there is not yet a major blockage in the artery. Certain patients will be prescribed aspirin combined with another antiplatelet drug – also known as dual antiplatelet therapy (DAPT). Some patients who have heart attacks, that have stents placed in their coronary arteries, or undergo coronary artery bypass graft surgery (CABG) are treated with two types of antiplatelet agents at the same time to prevent blood clotting. This is called dual antiplatelet therapy (DAPT). One antiplatelet agent is aspirin. Almost everyone with coronary artery disease, including those who have had a heart attack, stent, or CABG are treated with aspirin for the rest of their lives. A second type of antiplatelet agent, called a P2Y12 inhibitor, is usually prescribed for months or years in addition to the aspirin therapy. The type of medication and the duration of your treatment will vary based on your condition and other risk factors. The risks and benefits of DAPT should be discussed with your health care provider. If you did not have a heart attack, but have atherosclerosis in your coronary arteries and had a stent placed , in addition to aspirin, you should be on clopidogrel for at least 1-6 months, depending on the type of stent which was placed, risk of clotting the stent, and bleeding risk. If you had a heart attack and a coronary artery stent placed, or you are being treated with medical therapy (no stent, clot buster or surgery) , in addition to aspirin, you should also be on a P2Y12 inhibitor for 6-12 months. In some cases, it may be advisable to be on DAPT longer. This will need to be discussed with your healthcare provider. The three P2Y12 inhibitors currently available that could be prescribed are clopidogrel, prasugrel, and ticagrelor. Studies have shown that two of these drugs (ticagrelor, prasugrel) are “stronger” than clopidogrel, and are a little better at decreasing the complications of blood clots. These two stronger agents, however, slightly increase bleeding. One of these drugs (prasugrel) should not be used by patients who have had a stroke or a transient ischemic attack (TIA). You will be prescribed the drug that is best for you, based on your risk of blood clots and bleeding. For example, according to the FDA(link opens in new window)(link opens in new window)(link opens in new window) , clopidogrel does decrease the risk of stroke and MI, but does not change the risk of death for specific patients. The choice of what type of medication, cost of the medication and duration of treatment will be determined in discussions with your health care provider. Some patients who undergo coronary artery bypass surgery may be treated with a P2Y12 inhibitor for a year after the bypass operation. After this, the P2Y12 inhibitor might be stopped, but aspirin is usually continued long-term. Your surgeon will discuss if this treatment will be needed. These are general recommendations for the duration and type of dual anti-platelet therapy which could be used after coronary artery stenting, heart attack and CABG. Again, it is important to talk to your health care provider about your treatment plan. Print a patient information sheet on DAPT (PDF) . Commonly prescribed include: Benazepril (Lotensin) Captopril (Capoten) Enalapril (Vasotec) Fosinopril (Monopril) Lisinopril (Prinivil, Zestril) Moexipril (Univasc) Perindopril (Aceon) Quinapril (Accupril) Ramipril (Altace) Trandolapril (Mavik) What the Medication Does Expands blood vessels and decreases resistance by lowering levels of angiotensin II. Allows blood to flow more easily and makes the heart's work easier or more efficient. Reason for Medication Used to treat or improve symptoms of cardiovascular conditions including high blood pressure and heart failure . (Also known as ARBs) Commonly prescribed include: Azilsartan (Edarbi) Candesartan (Atacand) Eprosartan (Teveten) Irbesartan (Avapro) Losartan (Cozaar) Olmesartan (Benicar) Telmisartan (Micardis) Valsartan (Diovan) What the Medication Does Rather than lowering levels of angiotensin II (as ACE inhibitors do) angiotensin II receptor blockers prevent this chemical from having any effect on the heart and blood vessels. This keeps blood pressure from rising. Reason for Medication Used to treat or improve symptoms of cardiovascular conditions including high blood pressure and heart failure. ARNIs are a drug combination of a neprilysin inhibitor and an ARB. Commonly prescribed include: Sacubitril/valsartan (Entresto) What the Medication Does Neprilysin is an enzyme that breaks down natural substances in the body that open narrowed arteries. By limiting the effect of neprilysin, it increases the effects of these substances and improves artery opening and blood flow, reduces sodium (salt) retention, and decreases strain on the heart. Reason for Medication For the treatment of heart failure (Also known as Beta-Adrenergic Blocking Agents) Commonly prescribed include: Acebutolol (Sectral) Atenolol (Tenormin) Betaxolol (Kerlone) Bisoprolol/hydrochlorothiazide (Ziac) Bisoprolol (Zebeta) Metoprolol (Lopressor, Toprol XL) Nadolol (Corgard) Propranolol (Inderal) Sotalol (Betapace) What the Medication Does Decreases the heart rate and force of contraction, which lowers blood pressure and makes the heart beat more slowly and with less force. Reason for Medication Used to lower blood pressure. Used for cardiac arrhythmias (abnormal heart rhythms) Used to treat chest pain (angina) Used to help prevent future heart attacks in patients who have had a heart attack. Combined alpha and beta-blockers are used to treat high blood pressure and heart failure. Commonly prescribed include: Carvedilol (Coreg, Coreg CR) Labetalol hydrochloride (Normodyne, Trandate) A noted possible side effect of combined alpha and beta-blockers: May cause a drop in blood pressure when you stand up (Also known as Calcium Antagonists or Calcium Blockers) Commonly prescribed include: Amlodipine (Norvasc) Diltiazem (Cardizem, Tiazac) Felodipine (Plendil) Nifedipine (Adalat, Procardia) Nimodipine (Nimotop) Nisoldipine (Sular) Verapamil (Calan, Verelan) What the Medication Does Interrupts the movement of calcium into the cells of the heart and blood vessels. May decrease the heart's pumping strength and relax blood vessels. Reason for Medication Used to treat high blood pressure, chest pain (angina) caused by reduced blood supply to the heart muscle and some arrhythmias (abnormal heart rhythms). Statins: Atorvastatin (Lipitor), Fluvastatin (Lescol), Lovastatin (Mevacor), Pitavastatin (Livalo), Pravastatin (Pravachol), Rosuvastatin (Crestor), Simvastatin (Zocor) Nicotinic acids: Niacin Cholesterol absorption inhibitor: Ezetimibe (Zetia) Combination statin and cholesterol absorption inhibitors: Ezetimibe/Simvastatin (Vytorin) What the Medication Does Various medications can lower blood cholesterol levels, but drugs other than statins are usually only used for patients in whom statins are not effective or who have serious side effects from statin therapy. They work in the body in different ways. Some affect the liver, some work in the intestines and some interrupt the formation of cholesterol from circulating in the blood. Watch an animation of how statins work. Reason for Medication Used to lower LDL ("bad") cholesterol. *Some cholesterol-lowering medications may interact with grapefruit, grapefruit juice, pomegranate and pomegranate juice. Please talk to your health care provider about any potential risks. Commonly prescribed include: Digoxin (Lanoxin) What the Medication Does Increases the force of the heart's contractions. Can be beneficial in treating heart failure and irregular heartbeats. Reason for Medication Used to relieve heart failure symptoms, especially when the patient isn't responding to other standard treatments including ACE inhibitors, ARBs and diuretics. Also slows certain types of irregular heartbeat (arrhythmias), particularly atrial fibrillation . (Also known as Water Pills) Commonly prescribed include: Acetazolamide (Diamox) Amiloride (Midamor) Bumetanide (Bumex) Chlorothiazide (Diuril) Chlorthalidone (Hygroton) Furosemide (Lasix) Hydro-chlorothiazide (Esidrix, Hydrodiuril) Indapamide (Lozol) Metalozone (Zaroxolyn) Spironolactone (Aldactone) Torsemide (Demadex) What the Medication Does Causes the body to rid itself of excess fluids and sodium through urination. Helps to reduce the heart's workload. Also decreases the buildup of fluid in the lungs and other parts of the body, such as the ankles and legs. Different diuretics remove fluid at varied rates and through different methods. Reason for Medication Used to help lower blood pressure. Used to help reduce swelling (edema) from excess buildup of fluid in the body. Commonly prescribed include: Isosorbide dinitrate (Isordil) Isosorbide mononitrate (Imdur) Hydralazine (Apresoline) Nitroglycerin (Nitro Bid, Nitro Stat) Minoxidil What the Medication Does Relaxes blood vessels and decreases blood pressure. A category of vasodilators called nitrates increases the supply of blood and oxygen to the heart while reducing its workload which can ease chest pain (angina). Nitroglycerin is available as a pill to be swallowed or absorbed under the tongue (sublingual), a spray, and as a topical application (cream). Reason for Medication Used to ease chest pain (angina) What is a Heart Attack? (PDF) How Will I Recover? (PDF) Heart Attack Discharge Worksheet (PDF) Heart Attack Discharge Worksheet (Spanish) (PDF) 5 Ways to Lower Your Risk of a Second Heart Attack (PDF) 5 Ways to Lower Your Risk of a Second Heart Attack - Spanish (PDF) Cardiac Rehab Referral Card (PDF) Cardiac Rehab Referral Card (Spanish) (PDF) What Are the Warning Signs of Heart Attack? (PDF) Common Heart Attack Warning Signs (PDF) Written by American Heart Association editorial staff and reviewed by science and medicine advisers. See our editorial policies and staff . (* Some medications are commonly called blood thinners because they can help reduce a blood clot from forming. There are three main types of blood thinners that patients commonly take: anticoagulants like warfarin or heparin, antiplatelet drugs like aspirin, and fibrinolytics like tPA (tissue plasminogen activator). Each type of medication has a specific function to prevent a blood clot from forming or causing a blocked blood vessel, heart attack, or stroke.) The American Heart Association receives support from pharmaceutical and biotech companies, device manufacturers and health insurance providers whose products may be mentioned in this article. The American Heart Association maintains strict policies preventing supporters from influencing science-based health information. A list of supporters can be found here. Source: https://www.heart.org/en/health-topics/heart-attack/treatment-of-a-heart-attack/cardiac-medications
Merck
Pharmaceutical Companies
Merck, based in Kenilworth, New Jersey, is a global healthcare leader working to help the world be well. Through our prescription medicines, vaccines, biologic therapies, and consumer care and animal health products, we work with customers and operate in more than 140 countries to deliver innovative health solutions. We also demonstrate our commitment to increasing access to healthcare through far-reaching policies, programs and partnerships. Our product offering categories include heart and respiratory health, infectious diseases, sun care and women's health. We continue to focus our research on conditions that affect millions of people around the world - diseases like Alzheimer's, diabetes and cancer - while expanding our strengths in areas like vaccines and biologics. We also devote extensive time and energy to increasing access to medicines and vaccines through far-reaching programs that donate and deliver our products to the people who need them. At Merck, we're applying our global reach, financial strength and scientific excellence to do more of what we're passionate about: improving health and improving lives. We run to, not from, the world’s biggest health challenges. Source: https://merck.com
Novartis
Pharmaceutical Companies
Novartis provides healthcare solutions that improve and extend people’s lives. We use science-based innovation to address some of society’s most challenging healthcare issues. We discover and develop breakthrough treatments and find new ways to deliver them to as many people as possible. Our company is focused on industry-leading divisions with innovation power and global scale: pharmaceuticals, eye care and generic medicines Novartis is headquartered in Basel, Switzerland. Novartis Group companies employ approximately 120,000 associates and its products are available in more than 180 countries around the world. Our purpose is to reimagine medicine to improve and extend people's lives. We use innovative science and technology to address some of society's most challenging healthcare issues. We discover and develop breakthrough treatments and find new ways to deliver them to as many people as possible. We also aim to reward those who invest their money, time and ideas in our company. Benefitting from our continued focus on innovation, Novartis has one of the industry’s most competitive pipelines with more than 150 projects in clinical development. Many of these projects, which include new molecular entities as well as additional indications and different formulations for marketed products, are for medicines that could significantly advance treatment standards for patients worldwide. Source: https://www.novartis.com/
Pfizer
Pharmaceutical Companies
At Pfizer, we apply science and our global resources to bring therapies to people that extend and significantly improve their lives. We strive to set the standard for quality, safety and value in the discovery, development and manufacture of health care products, including innovative medicines and vaccines. Every day, Pfizer colleagues work across developed and emerging markets to advance wellness, prevention, treatments and cures that challenge the most feared diseases of our time. Consistent with our responsibility as one of the world's premier innovative biopharmaceutical companies, we collaborate with health care providers, governments and local communities to support and expand access to reliable, affordable health care around the world. For more than 150 years, we have worked to make a difference for all who rely on us. We’re in relentless pursuit of breakthroughs that change patients’ lives. We innovate every day to make the world a healthier place. It was Charles Pfizer’s vision at the beginning and it holds true today. Our unique resources allow us to do more for people. Using our global presence and scale, we’re able to make a difference in local communities and the world around us. Source: https://www.pfizer.com/
Roche
Pharmaceutical Companies
Throughout our 125-year history, Roche has grown into one of the world’s largest biotech companies, as well as a leading provider of in-vitro diagnostics and a global supplier of transformative innovative solutions across major disease areas. Our commitment to our people, partners, stakeholders and, most importantly, our patients remains as strong as it was on the first day of our journey. We focus on finding new medicines and diagnostics and establishing data-based insights that evolve the practice of medicine and help patients live longer, better lives. Healthcare is undergoing tremendous changes but our vision is clear. We are doing now what patients need next. From developing diagnostics and treatments, to harnessing the power of data to shape innovations of the future, we are an integrated healthcare company with a culture of integrity, courage and passion. For over 125 years, we’ve been developing diagnostics and medicines for a wide range of chronic and life threatening health conditions that continue to revolutionise healthcare. Being a family-owned company allows us to focus on long-lasting investments, take greater risks and explore innovative new ways to improve people’s health around the world. As a global leader in healthcare, we are one of the world’s largest biotech companies and the leading supplier of in-vitro diagnostics. We’re an innovator across major disease areas, including oncology, neurology, infectious diseases, and ophthalmology. We’ve partnered with many forward-thinking, entrepreneurial and groundbreaking organisations that have one thing in common - the belief that cutting-edge science and technology can and will improve human health. Cardiometabolic diseases are one of the greatest challenges we face. Our focus lies in countering the threat through innovative diagnostic and preventive solutions. Cardiometabolic disease is the number one cause of mortality, accounting for 31% of all global deaths—75% of which occur in low- and middle-income countries. Cardiometabolic disease is not a single ailment, but rather a spectrum of conditions.1 Early intervention is crucial to prevent complications. Most cardiovascular diseases can be prevented by addressing certain risk factors, such as tobacco use, unhealthy diet and obesity, physical inactivity, and harmful use of alcohol. However, the reality of many situations is that early warning signs are ignored and diagnostic solutions are required to inform appropriate intervention. We are focused on bringing better diagnostics solutions to support early intervention and improve outcomes. Today, advanced technologies and our evolved understanding of disease present new opportunities to personalise treatment, reduce unnecessary costs, and protect people in their time of need. The use of tests to assess risk, screen, diagnose, predict, and monitor cardiac disease have been essential tools in protecting patients, helping to reduce anxiety, avoid overcrowding of the emergency department, and help save lives. American College for Cardiology. Cardiometabolic Initiatives. https://www.acc.org/tools-and-practice-support/quality-programs/cardiometabolic-health-alliance . Accessed March 9, 2021. Source: https://www.roche.com/
Sanofi
Pharmaceutical Companies
Headquartered in Bridgewater, New Jersey, Sanofi in the United States employs more than 12,500 professionals throughout the country. Sanofi is comprised of three core business units: Specialty Care, Vaccines and General Medicines. Consumer Healthcare will become a standalone business unit. Around the world, more than 100,000 people at Sanofi are dedicated to making a difference in patients' daily lives, wherever they live, and enabling them to enjoy a healthier life. Source: https://www.sanofi.us/en/about-us
United Therapeutics
Pharmaceutical Companies
United Therapeutics is a biotechnology company focused on the development and commercialization of unique products to address the unmet medical needs of patients with chronic and life-threatening conditions. We build on the strength of our research and development expertise and a distinctive, entrepreneurial culture that encourages diversity, innovation, creativity, sustainability, and, simply, fun. Since inception our mission has been to find a cure for pulmonary arterial hypertension and other life-threatening diseases. Toward this goal we have successfully gained FDA approval for five medicines, we are always conducting new clinical trials, and we are working to create an unlimited supply of manufactured organs for transplantation. We are the first publicly-traded biotech or pharmaceutical company to take the form of a public benefit corporation (PBC) . Our public benefit purpose is to provide a brighter future for patients through (a) the development of novel pharmaceutical therapies; and (b) technologies that expand the availability of transplantable organs. At the same time, we seek to provide our shareholders with superior financial performance and our communities with earth-sensitive energy utilization. You can learn more about what it means to be a PBC here . Source: https://www.unither.com/