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Perspectum - Envisioning a future of precision health care
Perspectum is an innovative company in the field of precision health technology delivering advanced solutions to health care providers. Our best-in-class technology is noninvasive and generates clear and understandable reports aiding clinical decision-making as well as supporting patient engagement.
A new way to see precision health
We deliver advanced imaging solutions that can help doctors make better decisions, personalize care for patients, and ensure better outcomes.
Physician Education Hub
Sharing important updates from hepatology, radiology, oncology, and the role of noninvasive diagnostics in these fields.
Welcome back to our Physician Education Hub, and greetings from Chicago. I’ve been at RSNA many times, and in recent years I have witnessed the growth in imaging technologies directed at the important challenge of diagnosing and treating liver disease. This year has been no exception, with notable developments in the applications of MRI, PET/CT, and ultrasound for the detection and diagnosis of both chronic liver disease and cancer (e.g., LI-RADS), highlighting the vital role radiology plays in this field. There have also been some promising developments in the utility of MRI in treatment planning and monitoring the effectiveness of interventions (e.g., Yttrium-90 therapy) in patients with liver cancer.
Highlighted Article
Delving deeper into these exciting times for liver imaging, an area of particular interest at RSNA, is the growing role of artificial intelligence (AI) in gastrointestinal radiology, which is covered in several sessions. On this topic, I’d like to introduce a paper recently published in Applied Radiology, where Dr. Matt Kelly walks us through how AI and convolutional neural network (CNN)-based approaches can save radiology time while also reducing subjectivity and inter-reader variability associated with conventional techniques. For example, AI- and CNN-based approaches have been used successfully in liver volumetry and quantitative three-dimensional reconstruction of the biliary tree from MRI (see Figure 1). The article also recognizes the need for widespread clinical adoption of AI in regulatory-cleared products to enable seamless integration into the radiology workflow. This should bridge the gap to the clinic and address challenges in liver disease management, imaging chronic liver diseases, and liver cancer, while ensuring that the role of radiology in managing these conditions continues to evolve. -Dr. Carlos Duncker READ THE ARTICLE READ PREVIOUS ARTICLES
Figure 1. AI- and CNN-based approaches are used to automatically extract liver volume in Hepatica (top row) and the biliary tree in MRCP+ (bottom row). Perspectum’s Hepatica is a tool for the noninvasive assessment of liver volumetry and health from MRI using corrected T1 (cT1). Perspectum’s MRCP+ is a noninvasive tool for quantitative assessment of the biliary tree and pancreatic duct. Figure adapted from Kelly, M. (2022). Applied Radiology
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Disclosures
- Dr. Carlos Duncker and Dr. Matt Kelly are Perspectum employees.
- LiverMultiScan, Hepatica, cT1 and MRCP+ are manufactured by Perspectum.
Unmatched, integrated data intelligence
Conventional diagnostics give you one-dimensional, incomplete insights in black and white. Perspectum’s proprietary technology gives you a fuller picture — extracting biomarkers from imaging in an intuitive and streamlined way, which can lead to better diagnoses and outcomes.
FDA gives thumbs-up for Perspectum Diagnostics' biliary visualization software. Learn more
Safe, streamlined and accessible
Perspectum’s imaging solutions are safe, fast, and can offer more comprehensive diagnostics. We help doctors understand complex data and help deliver precision care to more patients. Learn more
Perspectum Products
LiverMultiScan
LiverMultiScan is a noninvasive MRI scan that accurately assesses signs of liver disease, offering a complete picture of liver health.
See your liver like never before
LiverMultiScan is a unique noninvasive tool offering you and your patients an easy-to-understand report to provide quantitative metrics that may empower clinicians with information to assess the current state of liver disease.
Treatments exist today that enable patients to manage and even reverse liver disease. Life-style adjustments and some additional approaches have been employed successfully. LiverMultiScan offers a comprehensive view of liver health and allows monitoring of the effectiveness of treatment.
Unique Category III CPT® Codes - LiverMultiScan
Quantitative multiparametric MR 0648T & +0649T
Category III 0648T - LiverMultiScan
CPT Code +0649T – LiverMultiScan add-on to abdominal MRI w/wo contrast
Download your version of "A Guide to Interpreting Liver Tissue Characterization" VIEW PRODUCT GUIDES
MRCP+
This ground-breaking new quantitative imaging tool uses artificial intelligence led technology to enhance MRCP images. MRCP+ creates true 3D rendered models of enhanced data and metrics to facilitate visualization and quantitative assessment of the biliary tree and pancreatic duct.
An advanced biliary visualization software that:
•Quantitatively analyses the biliary tree and pancreatic duct•Uses a noninvasive method without contrast
•Can be generated using historical MRCP images
•Requires no additional hardware, reducing capital expenditure
What is MRCP+?
MRCP+ is a noninvasive diagnostic tool that calculates quantitative 3D biliary system models.1 It enables the measurement of bile duct widths and automatic detection of regions of variation. MRCP+ includes tools for interactive segmentation and labelling of the biliary system and structures. It allows for regional volumetric analysis of the biliary tree, pancreatic duct, and gallbladder.Combining image viewing, processing, and reporting tools, the quantitative metrics provided are designed to support physicians in the visualization, evaluation, and reporting of hepatobiliary structures.
This information is provided through software-as-a-service in an easy-to-read report delivered directly to the radiologists or referring clinicians.
MRCP+ is available clinically, with FDA 510(k) clearance and CE marking.
The American Medical Association (AMA) issued two Current Procedural Terminology (CPT) codes for the Perspectum MRCP+.
The following Category III CPT codes may be reported by physicians, hospitals for outpatient services, Independent Diagnostic Testing Facilities and Ambulatory Surgery Centers: 0723T and +0724T.
CoverScan
The world’s first quantitative imaging solution for the assessment of multi-organ tissue characteristics, function, and size using a single, non-contrast MRI scan. This noninvasive technology can support clinical decision-making by quantifying metrics from images of the heart, liver, lungs, kidneys, pancreas, and spleen.
What is CoverScan?
CoverScan is a tool for quantifying the characteristics of six different organs using a single noninvasive scan, enabling clinicians to visualize and assess multi-organ health. Referring clinicians are provided with a report of 49 metrics from multiparametric MR data for easy assessment of multi-organ function relative to reference ranges.
The information provided by CoverScan, in conjunction with other tests and clinical evaluation of the patient, may form part of a clinical decision-making pathway and enable physicians to make more informed clinical decisions for patients. Importantly, repeated analyses using CoverScan may aid clinicians to monitor patients and personalize treatments.
CoverScan is an advanced cloud-based software suite, delivered as a software as a service solution, and uses existing clinical MR infrastructure.
In the U.K., the multiparametric multi-organ imaging technology is available as a tool to aid diagnoses for patients with multi-systemic diseases such as long COVID (1) or insulin resistance (e.g., metabolic syndrome and diabetes mellitus). It has been available within the U.K.’s NHS since January 2021, under the MHRA's temporary authorization, in response to the COVID-19 pandemic. CoverScan 1.0 (Siemens 1.5T and GE 1.5T) received full UKCA clearance in May 2022.
In the U.S., CoverScan 1.0 (Siemens 1.5T scanner) has been available clinically, with FDA 510(k) clearance since May 2022.
The world’s first quantitative imaging solution for the assessment of multi-organ tissue characteristics, function, and size using a single, non-contrast MRI scan. This noninvasive technology can support clinical decision-making by quantifying metrics from images of the heart, liver, lungs, kidneys, pancreas, and spleen.
Learn more about the CoverScan study and UK clinical trials. VIEW STIMULATE STUDY
Hepatica
Improving accuracy of liver health and volume assessment to support better pre-surgical decision making for patients with liver cancer.
What is Hepatica?
- Hepatica is a clinical and surgical decision support tool.
- Artificial intelligence-driven delineation of the liver and individual Couinaud segments in a single report containing quantitative metrics and images.
- Demonstrated utility in liver cancer by identifying patients at risk of poor outcomes and longer hospital stay after resection surgery.2
- Potential to enable cost savings through lowering the post-surgical complication rate, reducing the associated in-patient hospital stay and thus improving post-operative patient outcomes.
Improving accuracy of liver health and volume assessment to support better pre-surgical decision making for patients with liver cancer.
Liver health assessment and visualization on a single platform
- Patient-friendly reports
- Seamless integration into workflow through a PACS-integrated cloud-based service
- AI-driven delineation of liver volume and individual Couinaud segments
- MRI-based, therefore no radiation risk, giving your patients a safer experience
Improving accuracy of liver health and volume assessment to support better pre-surgical decision making for patients with liver cancer.
Couinaud segment analysis
Liver fibro-inflammation (cT1), fat (PDFF) and volume are quantified for individual Couinaud segments. This can assist clinicians in accurately predicting the future liver remnant (FLR) to inform surgical decision making.
Whole liver analysis:
Built on LiverMultiScan technology that provides validated biomarkers of liver health (cT1 and PDFF) across the whole liver and has been shown to predict clinical outcomes4–6. Provides 3D visualization and quantification of whole liver volume.
Supporting clinical decision making:
A study illustrating that pre-treatment assessment could improve post-treatment outcomes included two patients with similar pre-operative characteristics who had liver resection for colorectal liver metastases (CRLM) but different post-operative outcomes (Figure 1).3
Product Description Library: https://www.perspectum.com/our-products/product-information-library/
Couinaud segment analysis
Liver fibro-inflammation (cT1), fat (PDFF) and volume are quantified for individual Couinaud segments. This can assist clinicians in accurately predicting the future liver remnant (FLR) to inform surgical decision making.
Figure 1: Quantitative multiparametric MRI allows safe surgical planning in patients undergoing liver resection for colorectal liver metastases: Report of two patients.3
Patient 1
- Hepatica indicated high fibro-inflammation (cT1) and fat (PDFF)
- Future liver remnant volume: 23%
- Post-hepatectomy liver failure (PHLF)
- Information may have changed surgical plan, averting PHLF that delayed the patient’s recovery
Patient 2
- Hepatica indicated normal fibro-inflammation (cT1) and fat (PDFF)
- Future liver remnant volume: 29%
- Uneventful post-operative course and short hospital stay
- Information would justify surgical plan
Coding & Reimbursement
The American Medical Association (AMA) issued two Current Procedural Terminology (CPT) commonly billed codes for the Perspectum Hepatica. The following Category III CPT codes may be reported by physicians, hospitals for outpatient services, Independent Diagnostic Testing Facilities and Ambulatory Surgery Centers: 0648T and +0649T.
CPT Code: 0648T – HepaticaCPT Code: +0649T – Hepatica add-on to abdominal MRI w/wo contrast
Learn more about Hepatica
LEARN ABOUT CLINICAL TRIALS
GET THIS FOR YOUR PATIENTS
Download "A Guide to Interpreting Liver Tissue Characterization for Clinicians" VIEW PRODUCT GUIDES
Hepatica
Patient-first approach
We believe the voice of the patient matters and that each case is unique. Our goal is to enable healthcare providers to tailor precision medicine to the needs of the individual. Learn more
Proven leadership in healthcare
Our approach to patient care draws on the expertise of the renowned physicians and scientists who lead our company. Learn more
Perspectum Offices
Head Office - UK
Gemini One
5520 John Smith Drive
Oxford, OX4 2LL
United Kingdom
+44 (0) 1865 655 343
[email protected]
Singapore Office
42 Tras Street
03-01 and 03-03
Singapore 078981
[email protected]
Dallas Office
600 North Pearl St, Suite 1960
Plaza of The Americas
Dallas, TX, 75201
USA
+1.972.803.5501
[email protected]
Source: https://www.perspectum.com/